SupplementsProactive HealthImmune HealthWellmune AdaptWellmune® Adapt Research Studies

Wellmune® Research Studies

Wellmune® is a proprietary baker’s yeast beta 1,3/1,6 glucan postbiotic with a unique structure, source and mechanism of action.

Over a dozen clinical studies on over 2,300 adults and children demonstrate Wellmune’s ability to:

  • Support general immune health
  • Maintain overall physical health
  • Help the body adapt to the effects of stress
  • Promote healthy energy levels and mental clarity

 

Comparison of structural differences between yeast β-glucan sourced from different strains of saccharomyces cerevisiae and processed using proprietary manufacturing processes

In this study in the journal Food Chemistry, researchers explored structural differences of five commercial samples of yeast β-glucan, including β-glucan content and the yeast storage carbohydrate, glycogen. The findings confirm that each proprietary source of yeast β-glucan has a unique purity profile, branching and linkage patterns that determine the chemical structure and composition.

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Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomised Controlled Trial

In this Journal of Dietary Supplements study, researchers compared the effect of dairy-based beverages containing 250 mg of Wellmune baker’s yeast b-glucan to a macronutrient and calorie-matched control on upper respiratory tract infection (URTI) in marathon runners. Consumption of Wellmune decreased URTI symptomatic days, specific URTI symptom severity and missed post-marathon workout days due to URTI, without affecting duration and number of URTI episodes.

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Baker’s Yeast Beta-Glucan Supplement Reduces Upper Respiratory Symptoms and Improves Mood State in Stressed Women

This study in the Journal of the American College of Nutrition investigated the effect of Wellmune on upper respiratory tract symptoms and psychological well-being in women with moderate levels of psychological stress.

The findings show that Wellmune reduces upper respiratory symptoms and improves mood state in stressed subjects, helping to maintain immune protection against daily stressors.

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Baker’s Yeast Beta-Glucan Decreases Episodes of Common Childhood Illness in Children Aged 1-4 during Cold Season in China

In this Journal of Nutrition & Food Sciences study, researchers evaluated the ability of Wellmune to reduce the number of episodes of common childhood illness in 174 Chinese children aged 1 to 4 years old. During a 12-week randomised, double-blinded study, children in the Wellmune group experienced fewer common childhood infectious illness episodes during the study, compared to the placebo group. Additionally, Wellmune was found to be well tolerated by the children.

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Bibliography

Our larger portfolio of published clinical studies demonstrate Wellmune’s ability to support the immune health of the general population (across the lifespan from children to elderly), including those experiencing many different forms of stress such as exercise stress, physical stress and lifestyle stress. Additionally, multiple publications deepen our understanding of the key biomarkers impacted by Wellmune.

Boutros JA, Magee AS, Cox D. (2022) Comparison of Structural Differences Between Yeast β-glucan Sourced From Different strains of Saccharomyces Cerevisiae and Processed Using Proprietary Manufacturing Processes. Food Chemistry (published online ahead of print 28 July, 2021), 367:130708.

Mah E, Kaden VN, Kelley KM, Liska DJ. (2020) Beverage Containing Dispersible Yeast β-Glucan Decreases Cold/Flu Symptomatic Days After Intense Exercise: A Randomized Controlled Trial.  Journal of Dietary Supplements 17(2): 200-210.

Talbott SM, Talbott JA. (2012) Baker’s Yeast Beta-Glucan Supplement Reduces Upper Respiratory Symptoms and Improves Mood State in Stressed Women. Journal of the American College of Nutrition 31:295-300.

Meng F. (2016) Baker’s Yeast Beta-Glucan Decreases Episodes of Common Childhood Illness In 1 to 4-Year-Old Children during Cold Season in China. Journal of Nutrition & Food Sciences 6:518.

Talbott S, Talbott J. (2009) Effect of Beta 1,3/1,6 Glucan on Upper Respiratory Tract Infection Symptoms and Mood State in Marathon Athletes. Journal of Sports Science and Medicine 8:509-515.

Talbott SM, Talbott JA, Talbott TL, Dingler E. (2013) ß-Glucan Supplementation, Allergy Symptoms and Quality of Life in Self-Described Ragweed Allergy Sufferers. Food Science & Nutrition 1:90-101.

Talbott S, Talbott J. (2010) Beta 1,3/1,6 Glucan Decreases Upper Respiratory Tract Infection Symptoms and Improves Psychological Well-Being in Moderate to Highly-Stressed Subjects. Agro FOOD Industry Hi-Tech 21:21-24. 

De Marco Castro E, Calder PC, Roche HM. (2021) b-1,3/1,6 glucans and Immunity: State of the Art and Future Directions. Molecular Nutrition and Food Research 65(1):e1901071.

McFarlin BK, Venable AS, Carpenter KC, Henning AL, Ogenstad S. (2017) Oral Supplementation with Baker’s Yeast Beta Glucan Is Associated with Altered Monocytes, T Cells and Cytokines following a Bout of Strenuous Exercise. Frontiers in Physiology 8:786.

Fuller R, Moore MV, Lewith G, Stuart BL, Ormiston RV, Fisk HL, Noakes PS, Calder PC. (2017) Yeast-Derived Beta 1,3/1,6 Glucan, Upper Respiratory Tract Infection and Innate Immunity in Older Adults. Nutrition 39-40:30-35.

Pontes MV, Ribeiro TCM, Ribeiro H, de Mattos AP, Almeida IR, Leal VM, Cabral GN, Stolz S, Zhuang W, Scalabrin DMF. (2016) Cow’s Milk-Based Beverage Consumption in 1- to 4-Year-Olds and Allergic Manifestations: an RCT. Nutrition Journal 15:19-28.

Li F, Jin X, Liu B, Zhuang W, Scalabrin D. (2014) Follow-up Formula Consumption in 3- to 4-Year-Olds and Respiratory Infections: An RCT. Pediatrics 133:e1533-40.

McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. (2013) Baker’s Yeast Beta Glucan Supplementation Increases Salivary IgA and Decreases Cold/Flu Symptomatic Days After Intense Exercise. Journal of Dietary Supplements 10:171-183.

Carpenter KC, Breslin WL, Davidson T, Adams A, McFarlin BK. (2013) Baker’s Yeast Beta-Glucan Supplementation Increases Monocytes and Cytokines Post-Exercise: Implications of Infection Risk? British Journal of Nutrition 109:478-486.

Fuller R, Butt H, Noakes PS, Kenyon J, Yam TS, Calder PC. (2012) Influence of Yeast-Derived 1,3/1,6 Glucopolysaccharide on Circulating Cytokines and Chemokines with Respect to Upper Respiratory Tract Infections. Nutrition 28:665-669.

Feldman S, Schwartz HI, Kalman DS, Mayers A, Kohrman HM, Clemens R, Krieger DR. (2009) Randomized Phase II Clinical Trials of Wellmune® for Immune Support During Cold and Flu Season. Journal of Applied Research 9:30-42.

Harger-Domitrovich SG, Domitrovich JW, Ruby BC. (2008) Effects of an Immunomodulating Supplement on Upper Respiratory Tract Infection Symptoms in Wildland Firefighters. Medicine & Science in Sports & Exercise 40:S353.

SupplementsProactive HealthImmune HealthWellmune AdaptWellmune® Adapt Research Studies

Sensoril® Ashwagandha Research Studies

Sensoril is a well-researched ashwagandha root and leaf extract, studied for its role in cognitive health support.

Sensoril has been studied in over 12 published, preclinical and biomarker studies.  Clinical studies with Sensoril have been conducted in a wide range of participants focused on the cognitive health benefits, specifically around stress and sleep management. A study in chronically stressed adults supports Sensoril’s ability to provide stress management with a 62% reduction in overall everyday stress.

A Standardised Withania somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomised, Placebo-Controlled Study.

In this study in the Journal of American Nutrition Association, researchers explored the effects of Sensoril, an ashwaganda root and leaf extract, in chronically stressed humans in a modern clinical trial. Consumption of 125 mg/day of Sensoril resulted in significant improvement of mHAM-A scores for stress and anxiety by a reduction of 62% in overall everyday stress. Participants also experienced improvement in a reduction of stress biomarkers, including serum cortisol and C-reactive protein (CRP) compared to baseline when consuming Sensoril.

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Effect of standardised aqueous extract Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants.

In this study in the publication of Pharmacognosy Research, researchers evaluated the cognitive and psychomotor performances in healthy adults. Consumption of 500 mg BID of Sensoril resulted in significant improvements in reaction times for psychomotor tests compared to baseline and placebo. This research shows that Sensoril may improve mental stamina, including enhancing focus and the ability to concentrate.

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Effect of Withania somnifera extract on mental stress induced changes in hemodynamic properties and arterial wave reflections in healthy subjects.

In this study in the publication of, Current Topics in Nutraceutical Research, researchers evaluated the brachial blood pressure (BP), heart rate (HR), and arterial stiffness while performing mental stress tests in healthy participants. Consumption of 500 mg BID of Sensoril resulted in study participants experiencing a significant decrease in the mental stress induced changes on aortic pressure and augmentation index compared to baseline and placebo.

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